In the first stage of PSC there are no symptoms other than changes in the levels of certain liver enzymes. PSC can go undetected for several years and, if noticed, is often misdiagnosed. In the second stage, gradual inflammation and blocking of the bile ducts causes worsening illness and exhaustion. The final stage is marked by severe illness and liver failure — requiring a liver transplant.
The mean survival rate of children (and adults) with PSC without transplant is about 12 years from diagnosis. Even with a transplant, PSC frequently reoccurs, and the cycle repeats. More than half of all children with PSC also have Ulcerative Colitis and/or Crohn’s disease, and it is usually by blood tests or endoscopy of patients with these illnesses that PSC is first discovered.
Part of the mission of the Children’s PSC Foundation is to let the world know that oral vancomycin is a long-term treatment for PSC—not one that eliminates the disease, but that eliminates its symptoms and stops its progression. The other part of the Foundation’s mission is to turn that treatment into a permanent cure, through on-going support of research.
The Children’s PSC Foundation is dedicated to funding promising scientific research in pursuit of this cure and to bringing hope to the many children suffering with PSC.
We welcome you on our journey towards the cure, and thank you for supporting us in our endeavors.